Altered physiology of gastrointestinal vagal afferents following neurotrauma

The adaptability of the central nervous system has been revealed in several model systems. Of particular interest to system-injured individuals is ability for neural components be modified regain function. In both types neurotrauma, traumatic brain injury and spinal cord injury, primary parasympathetic control gastrointestinal tract, vagus nerve, remains anatomically intact. However, with or are highly susceptible dysfunctions. Such dysfunctions attribute higher morbidity mortality following injury. While vagal efferent output capable eliciting motor responses evidence suggests impairment afferents. Since sensory input drives output, this review will discuss normal altered anatomy physiology afferents better understand contributions afferent plasticity neurotrauma.